The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans

PSYCHIATRY RESEARCH

卷:177

Article

Du, Yanlei^1,3  Yang, Min¹  Yeh, Hung-Wen²  Wan, Yu-Jui Yvonne^1,3 

[1] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA

[2] Univ Kansas, Med Ctr, Dept Biostat, Kansas City, KS 66160 USA

[3] First Municipal Peoples Hosp Guangzhou, Guangzhou Med Coll, Dept Gastroenterol & Hepatol, Guangzhou 510180, Guangdong, Peoples R China

关键词: Alcoholism;    Dopamine receptor D4;    Mexican American;    Reward;    Polymorphism;   

DOI  :  10.1016/j.psychres.2010.02.021

来源: Elsevier

【 摘 要 】

In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24 h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free