Postischemic fish oil treatment confers task-dependent memory recovery

PHYSIOLOGY & BEHAVIOR

卷:177

Article

de Oliveira, Janaina Nicolau¹  Reis, Luane Oliveira¹  Fiuza Ferreira, Emilene Dias¹  Godinho, Jacqueline¹  Bacarin, Cristiano Correia¹  Soares, Ligia Mendes¹  Weffort de Oliveira, Rubia Maria¹  Milani, Humberto¹ 

[1] Univ Estadual Maringa, Hlth Sci Ctr, Dept Pharmacol & Therapeut, Ave Colombo 5790, BR-87020900 Maringa, Parana, Brazil

关键词: Global cerebral ischemia;    Memory deficits;    Neurodegeneration;    Fish oil;    Memory recovery;    Task-dependence;   

DOI  :  10.1016/j.physbeh.2017.05.009

来源: Elsevier

【 摘 要 】

A series of our previous studies demonstrated that fish oil (FO), equivalent to 300 mg/kg docosahexahenoic acid (DHA), facilitates memory recovery after transient, global cerebral ischemia (TGCI) in the aversive radial maze (AvRM). The present study sought to address two main issues: (i) whether the memory-protective effect of FO that has been observed in the AvRM can be replicated in the passive avoidance test (PAT) and object location test (OLT) and (ii) whether FO at doses that are lower than those used previously can also prevent TGCI-induced memory loss. In Experiment 1, naive rats were trained in the PAT, subjected to TGCI (4-vessel occlusion model), and tested for retrograde memory performance 8 and 15 days after ischemia. Fish oil (300 mg/kg/day DHA) was given orally for 8 days. The first dose was delivered 4 h postischemia. In Experiment 2, the rats were subjected to TGCI, treated with the same FO regimen, and then trained and tested in the OLT. In Experiment 3, the rats were trained in the AvRM, subjected to TGCI, administered FO (100, 200, and 300 mg/kg DHA), and tested for memory performance up to 3 weeks after TGCI. At the end of the behavioral tests, the brains were examined for neurodegeneration and neuroblast proliferation. All of the behavioral tests (PAT, OLT, and AvRM) were sensitive to ischemia, but only the AvRM was able to detect the memory-protective effect of FO. Ischemia-induced neurodegeneration and neuroblast proliferation were unaffected by FO treatment. These results suggest that (i) the beneficial effect of FO on memory recovery after TGCI is task-dependent, (ii) doses of FO < 300 mg/kg DHA can protect memory function in the radial maze, and (iii) cognitive recovery occurs in the absence of neuronal rescue and/or hippocampal neurogenesis.

【 授权许可】

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