Polarization multi-parametric imaging method for the inspection of cervix cell

OPTICS COMMUNICATIONS

卷:488

Article

Liu, Weiping¹  Xiong, Jichuan¹  Liu, Juan¹  Zhu, Jing²  Hu, Jinlian³  Hou, Lianping⁴  Marsh, John H.⁴  Yi, Muhua⁵  Liu, Xuefeng¹ 

[1] Nanjing Univ Sci & Technol, Sch Elect & Opt Engn, 200 Xiaolingwei, Nanjing 210094, Peoples R China

[2] Nanjing Univ Chinese Med, Jiangsu Key Lab Pharmacol & Safety Evaluat Chines, Nanjing, Peoples R China

[3] City Univ Hong Kong, Dept Biomed Engn, Hong Kong 999077, Peoples R China

[4] Univ Glasgow, James Watt Sch Engn, Glasgow G12 8QQ, Lanark, Scotland

[5] Southern Med Univ, Affiliated Dongguan Peoples Hosp, Dept Pathol, Dongguan 523059, Peoples R China

关键词: Polarization modulation;    Cervix cell;    Microscopic imaging;   

DOI  :  10.1016/j.optcom.2021.126846

来源: Elsevier

【 摘 要 】

Accurate identification of the shape and texture properties of cervical cell nuclei and cytoplasm in the pap smear test is crucial for the diagnosis of cervical cancer. Fast and high-precision polarization modulation in the Polarization Indirect Microscopic Imaging (PIMI) is achieved by utilizing a liquid crystal polarization rotator. Imaging results of cervical cells show that the PIMI method can resolve detailed fine structural features of a cervical cell which are invisible in conventional microscopy. It also demonstrated the ability of embossed three-dimensional visualization as that in differential interference contrast microscopy (DIC), but with finer structural features.

【 授权许可】

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