Aggregation-induced emission shining in the biomedical field: From bench to bedside

Engineered Regeneration

Luojia Chen¹  Yidan Sun²  Meijia Gu²  Qingrong Chen³  Yishen Liu³  Yuncong Yuan³ 

[1] Center for Type Culture Collection, Wuhan University, Wuhan, Hubei 430072, China;College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China;Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China;

关键词: Aggregation-induced emission (AIE);    Biomedical field;    Microscopic imaging;    Bioimaging;    Theranostics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Fluorogens with aggregation-induced emission characteristics (AIEgens) have been developed in an unprecedented manner in the biomedical field over the past decade, which is ascribable to their superior fluorescence quantum yields, photosensitivities, as well as their “turn-on” characteristics in their aggregate states. By deliberately engineering their molecular structures and nanocarriers, the input energies of AIEgens can be channeled into specific forms, thereby enabling bioimaging, phototherapy, and even synergetic therapy. Moreover, multiple targeting strategies have been tailored for nidus and pathogen localization that subsequently guide therapeutic processes. This review integrates application-oriented design strategies for AIEgens, demonstrating how microscopic imaging, bioimaging, and theranostics can be developed to combat tumors, pathogens, and other diseases, and critically discusses challenges and perspectives for clinical translation.

【 授权许可】

Unknown