Schizophrenia and birthplace of paternal and maternal grandfather in the Jerusalem perinatal cohort prospective study

SCHIZOPHRENIA RESEARCH

卷:111

Article

Harlap, S.^1,2  Perrin, M. C.¹  Deutsch, L.³  Kleinhaus, K.⁴  Nahon, D.⁵  Teitelbaum, A.⁶  Friedlander, Y.³  Malaspina, D.¹ 

[1] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA

[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA

[3] Hebrew Univ Jerusalem, Braun Sch Publ Hlth, Jerusalem, Israel

[4] Columbia Univ, Dept Psychiat, New York, NY USA

[5] Minist Hlth, Div Res Evaluat & Planning, Jerusalem, Israel

[6] Kfar Shaul Hosp, Jerusalem, Israel

关键词: Schizophrenia;    Jews;    Cohort studies;    Incidence;    Relative risk;    Maternal;    Paternal;    Grandfathers;   

DOI  :  10.1016/j.schres.2009.03.022

来源: Elsevier

【 摘 要 】

Some forms of epigenetic abnormalities transmitted to offspring are manifested in differences in disease incidence that depend on parent-of-origin. To explore whether such phenomena might operate in schizophrenia spectrum disorders, we estimated the relative incidence of these conditions in relation to parent-of-origin by considering the two grandfathers' countries of birth. In a prospective cohort of 88,829 offspring, born in Jerusalem in 1964-76 we identified 637 cases through Israel's psychiatric registry. Relative risks (RR) were estimated for paternal and maternal grandfathers' countries of birth using proportional hazards methods, controlling for parents' ages, low social class and duration of marriage. After adjusting for multiple observations, we found no significant differences between descendants of maternal or paternal grandfathers born in Iraq, Iran, Turkey, Syria, Yemen, Morocco, Algeria, Tunisia, Libya/Egypt, Poland, USSR, Czechoslovakia, Germany or the USA. Those with paternal grandfathers from Romania (RR = 1.9. 95% CI = 1.3-2.8) or Hungary (1.6, 1.0-2.6) showed an increased incidence; however, those with maternal grandfathers from these countries experienced reduced incidence (RR=0.5, 0.3-0.8 and 0.4, 0.2-0.8). In post-hoc analyses we found that results were similar whether the comparison groups were restricted to descendants of other Europeans or included those from Western Asia and North Africa; and effects of paternal grandfathers from Romania/Hungary were more pronounced in females, while effects of maternal grandfathers from these countries were similar in males and females. These post-hoc hypothesis-generating findings lead one to question whether some families with ancestors in Romania or Hungary might carry a variant or mutation at a parentally imprinted locus that is altering susceptibility to schizophrenia. Such a locus, if it exists, might involve the X chromosome. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

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