Retinal ganglion cells dysfunctions in schizophrenia patients with or without visual hallucinations

SCHIZOPHRENIA RESEARCH

卷:219

Article

Bernardin, Florent^1,2,3  Schwitzer, Thomas^1,2,3  Angioi-Duprez, Karine⁴  Giersch, Anne²  Jansen, Claire¹  Schwan, Raymund^1,2,3,5  Laprevote, Vincent^1,2,3 

[1] Univ Psychiat Adultes Grand Nancy, Pole Hosp, Ctr Psychotherap Nancy, Laxou, France

[2] Univ Strasbourg, Ctr Hosp Reg Univ Strasbourg, Pole Psychiat, INSERM U1114, Strasbourg, France

[3] Univ Lorraine, Vandoeuvre Les Nancy, France

[4] CHRU Nancy, Serv Ophtalmol, Nancy, France

[5] CHRU Nancy, Maison Addict, Nancy, France

关键词: Schizophrenia;    Retinal ganglion cells;    Retina;    Flash electroretinogram;    Pattern electroretinogram;    Visual hallucinations;   

DOI  :  10.1016/j.schres.2019.07.007

来源: Elsevier

【 摘 要 】

The electroretinogram has revealed photoreceptor, bipolar cell, and, in one prior study, retinal ganglion cell (RGC) dysfunction in schizophrenia. The structural abnormalities of the RGC are well documented in schizophre- nia and such abnormalities have been associated with visual hallucinations (VH) in neurological disorders. The goals of this study were: 1) to examine the functional responses of photoreceptors and RGC in schizophrenia pa- tients in comparison with healthy controls; and 2) to compare the extent of retinal dysfunction in schizophrenia patients with or without VH. We recorded the flash electroretinogram in scotopic and photopic conditions, and the pattern electroretinogram, in schizophrenia patients ( n = 29) and healthy controls (n = 29). Schizophrenia patients were divided in two groups: schizophrenia patients with VH (VH group, n = 12) and schizophrenia patients with auditory hallucina- tions or no hallucinations (AHNH group, n = 17). Our results replicate previous findings regarding photoreceptor dysfunction in schizophrenia. PERG results showed a signi ficant increase of the P50 implicit time in schizophrenia patients compared with controls (t(55) = 2.1, p < .05, d = 0.55) and a signi ficant increase of the N95 implicit time in schizophrenia patients compared with controls (t(55) = 4.2; p < .001, d = 0.66). We found an increased rod b -wave implicit time (dark -adapted 0.01 ERG) in the VH group compared to the AHNH group and to the control group, which was associated with lifetime VH score. Our results demonstrate a slowing of RGC signaling in schizophrenia patients, which could affect the quality of visual information reaching the visual cortex. The implications of the data for understanding VH in schizophrenia

【 授权许可】

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