Electoretinographic evidence of retinal ganglion cell -dependent function in schizophrenia

SCHIZOPHRENIA RESEARCH

卷:219

Article

Moghimi, Pantea⁷  Jimenez, Nathalia Torres^1,4,5  McLoon, Linda K.^1,4,5  Netoff, Theoden, I^1,4,6  Lee, Michael S.⁵  MacDonald, Angus, III^1,2,3  Miller, Robert F.^1,4,5 

[1] Univ Minnesota, Grad Program Neurosci, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Psychol, Minneapolis, MN USA

[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Neurosci, Minneapolis, MN USA

[5] Univ Minnesota, Dept Ophthalmol & Visual Neurosci, Minneapolis, MN USA

[6] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN USA

[7] Univ Chicago, Dept Neurobiol, Chicago, IL 60637 USA

关键词: Electroretinogram;    Schizophrenia;    NMDA receptor;    Pattern ERG;    PhNR;    Retina;    Retinal ganglion cells;    Biomarker;   

DOI  :  10.1016/j.schres.2019.09.005

来源: Elsevier

【 摘 要 】

Schizophrenia is a complex disorder that is diagnosed mainly with clinical observation and evaluation. Recent studies suggest that many people with schizophrenia have abnormalities in the function of the N - methyl- D -aspartate receptor (NMDAR). The retina is part of the central nervous system and expresses the NMDAR, raising the possibility of the early detection of NMDAR-related schizophrenia by detecting differences in retinal function. As a first -step, we used two non-invasive outpatient tests of retinal function, the photopic negative response (PhNR) of the light -adapted flash-electroretinogram (PhNR- fERG) and the pattern ERG (PERG), to test individuals with schizophrenia and controls to determine if there were measurable differences between the two populations. The PhNR-fERG showed that males with schizophrenia had a signi ficant increase in the variability of the overall response, which was not seen in the females with schizophrenia. Additionally at the brightest flash strength, there were signi fi- cant increases in the PhNR amplitude in people with schizophrenia that were maximal in controls. Our results show measurable dysfunction of retinal ganglion cells (RGCs) in schizophrenia using the PhNR- fERG, with a good deal of variability in the retinal responses of people with schizophrenia. The PhNR- fERG holds promise as a method to identify individuals more at risk for developing schizophrenia, and may help understand heterogeneity in etiology and response to treatment. ? 2019 Published by Elsevier B.V.

【 授权许可】

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