Memory blocking in schizophrenia reflects deficient retrieval control mechanisms

SCHIZOPHRENIA RESEARCH

卷:133

Article

Rass, Olga¹  Leynes, P. Andrew²  Hetrick, William P.^1,3,4  O'Donnell, Brian F.^1,3,4 

[1] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA

[2] Coll New Jersey, Dept Psychol, Ewing, NJ 08618 USA

[3] Larue D Carter Mem Hosp, Indianapolis, IN 46222 USA

[4] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

关键词: Schizophrenia;    Schizotypal personality disorder;    Word fragment completion;    Priming;    Retrieval control;   

DOI  :  10.1016/j.schres.2011.07.024

来源: Elsevier

【 摘 要 】

Retrieval interference and orthographic processing were evaluated in schizophrenia, schizotypal personality disorder, and non-psychiatric control participants using a word fragment completion paradigm. Participants studied solutions and later completed corresponding fragments preceded by solutions, orthographically similar blocking words, or ampersands. Although schizophrenia patients completed fewest fragments, they showed equivalent repetition priming and blocking magnitude, supporting intact orthographic processing. Schizophrenia patients were more likely to commit intrusions in the blocking condition, whereas control participants displayed better mental control because they were more likely to withhold the response. These results suggest schizophrenia patients show abnormal functioning of control mechanisms responsible for selection and inhibition of competitors. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free