Larger putamen size in antipsychotic-naive individuals with schizotypal personality disorder

SCHIZOPHRENIA RESEARCH

卷:143

Article

Chemerinski, Eran^1,2  Byne, William^1,2,3  Kolaitis, Jeanine C.¹  Glanton, Cathryn F.¹  Canfield, Emily L.¹  Newmark, Randall E.¹  Haznedar, M. Mehmet^1,2  Novakovic, Vladan¹  Chu, King-Wai³  Siever, Larry J.^1,2,3  Hazlett, Erin A.^1,3 

[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

[2] JJP VA Med Ctr, Dept Outpatient Psychiat, Bronx, NY 10468 USA

[3] JJP VA Med Ctr, MIRECC, Bronx, NY 10468 USA

关键词: Schizotypal personality disorder;    Putamen;    Caudate;    Striatum;    Schizophrenia;    MRI;    Striatal size;   

DOI  :  10.1016/j.schres.2012.11.003

来源: Elsevier

【 摘 要 】

Objective: To (a) compare the size of the dorsal and ventral striatum(caudate and putamen) in a large sample of antipsychotic-naive individuals with schizotypal personality disorder (SPD) and healthy control participants; (b) examine symptom correlates of striatal size in SPD. Methods: The left and right caudate and putamen were hand-traced on structural MRI at five dorsal to ventral slice levels in 76 SPD and 148 healthy control participants. A Group x Region (caudate, putamen) x Slice (1-5: ventral, 2, 3, 4, dorsal) x Hemisphere (left, right) mixed-model MANOVA was conducted on size relative to whole brain. Results: Primary results showed that compared with the controls, the SPD group showed (a) larger bilateral putamen size overall and this enlargement was more pronounced at the most ventral and dorsal levels; in contrast, there were no between-group differences in caudate volume; (b) larger bilateral size of the striatum ventrally, averaged across the caudate and putamen. Among the SPD group, larger striatal size ventrally, particularly in the left hemisphere was associated with less severe paranoid symptoms. Conclusions: Striatal size is abnormal in SPD and resembles that of patients with schizophrenia who respond well to antipsychotic treatment. The results suggest that striatal size may be an important endophenotype to consider when developing new pharmacological treatments and when studying factors mitigating psychosis. Published by Elsevier B.V.

【 授权许可】

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