Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:37

Review

Zorrilla, Eric P.¹  Koob, George F.¹ 

[1] Scripps Res Inst, Comm Neurobiol Addict Disorders, La Jolla, CA 92037 USA

关键词: Basolateral or medial or lateral or basomedial or central nucleus of the amygdala;    Striatum;    Extended amygdala;    Bed nucleus of the stria terminalis;    Nucleus accumbens;    Caudate;    Putamen;    Afferent or efferent or projection or circuit;    Incentive salience or motivation or reward;    Pavlovian or classical or instrumental or operant conditioning;    Addiction;    Obesity;   

DOI  :  10.1016/j.neubiorev.2012.11.019

来源: Elsevier

【 摘 要 】

In MacLean's triune brain, the amygdala putatively subserves motivated behavior by modulating the reptilian basal ganglia. Accordingly, Ann Kelley, with Domesick and Nauta, influentially showed that amygdalostriatal projections are much more extensive than were appreciated. They highlighted that amygdalar projections to the rostral ventromedial striatum converged with projections from the ventral tegmental area and cingulate cortex, forming a limbic striatum. Caudal of the anterior commissure, the entire striatum receives afferents from deep basal nuclei of the amygdala. Orthologous topographic projections subsequently were observed in fish, amphibians, and reptiles. Subsequent functional studies linked acquired value to action via this neuroanatomical substrate. From Dr. Kelley's work evolved insights into components of the distributed, interconnected network that subserves motivated behavior, including the nucleus accumbens shell and core and the striatal-like extended amygdala macrostructure. These heuristic frameworks provide a neuroanatomical basis for adaptively translating motivation into behavior. The ancient amygdala-to-striatum pathways remain a current functional thread not only for stimulus-response valuation, but also for the psychopathological plasticity that underlies addiction-related memory, craving and relapse. (C) 2012 Published by Elsevier Ltd.

【 授权许可】

Free