Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder

SCHIZOPHRENIA RESEARCH

卷:136

Article

Rass, Olga¹  Forsyth, Jennifer K.²  Krishnan, Giri P.³  Hetrick, William P.^1,4,5  Klaunig, Mallory J.^1,4  Breier, Alan^4,5  O'Donnell, Brian F.^1,4,5  Brenner, Colleen A.⁶ 

[1] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA

[2] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[3] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA

[4] Larue D Carter Mem Hosp, Indianapolis, IN 46222 USA

[5] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[6] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada

关键词: Electroencephalography;    Auditory steady state potentials;    Schizophrenia;    Schizotypal personality disorder;    First-degree relatives;   

DOI  :  10.1016/j.schres.2012.01.003

来源: Elsevier

【 摘 要 】

The power and phase synchronization of the auditory steady state response (ASSR) at 40 Hz stimulation is usually reduced in schizophrenia (SZ). The sensitivity of the 40 Hz ASSR to schizophrenia spectrum phenotypes, such as schizotypal personality disorder (SPD), or to familial risk has been less well characterized. We compared the ASSR of patients with SZ, persons with schizotypal personality disorder, first degree relatives of patients with SZ, and healthy control participants. ASSRs were obtained to 20, 30, 40 and 50 Hz click trains, and assessed using measures of power (mean trial power or MTP) and phase consistency (phase locking factor or PLF). The MTP to 40 Hz stimulation was reduced in relatives, and there was a trend for MTP reduction in SZ. The 40 Hz ASSR was not reduced in SPD participants. PLF did not differ among groups. These data suggest the 40 Hz ASSR is sensitive to familial risk factors associated with schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free