Computer-assisted cognitive remediation for schizophrenia: A randomized single-blind pilot study

SCHIZOPHRENIA RESEARCH

卷:139

Article

Rass, Olga¹  Forsyth, Jennifer K.²  Bolbecker, Amanda R.^1,3  Hetrick, William P.^1,3,4  Breier, Alan^3,4  Lysaker, Paul H.^4,5  O'Donnell, Brian F.^1,5 

[1] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA

[2] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[3] Larue D Carter Mem Hosp, Indianapolis, IN 46222 USA

[4] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[5] Richard L Roudebush VA Med Ctr, Indianapolis, IN 46202 USA

关键词: Schizophrenia;    Cognitive remediation;    Cognitive training;    Event-related potentials;    Auditory steady state potentials;    Intervention;   

DOI  :  10.1016/j.schres.2012.05.016

来源: Elsevier

【 摘 要 】

Cognitive impairment is a core symptom in schizophrenia that has a significant impact on psychosocial function, but shows a weak response to pharmacological treatment. Consequently, a variety of cognitive remediation strategies have been evaluated to improve cognitive function in schizophrenia. The efficacy of computer-based cognitive remediation as a stand-alone intervention on general measures of neuropsychological function remains unclear. We tested the effectiveness of biweekly training using computerized cognitive remediation programs on neuropsychological and event-related potential outcome measures. Schizophrenia patients were randomly assigned to cognitive remediation training (N=17), active control (TV-watching; N=17), or treatment-as-usual (N=10) groups for ten weeks and run in parallel. Cognitive and ERP measures revealed no differential improvement over time in the cognitive remediation group. Practice effects might explain change over time on several cognitive measures for all groups, consistent with studies indicating task-specific improvement. Computer-assisted cognitive remediation alone may not be sufficient for robust or generalized effects on cognitive and electrophysiological measures in schizophrenia patients. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

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