Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensation

SCHIZOPHRENIA RESEARCH

卷:117

Article

Kim, Miyoung A.¹  Tura, Emanuela²  Potkin, Steven G.¹  Fallon, James H.¹  Manoach, Dara S.^3,4  Calhoun, Vince D.^5,6  Turner, Jessica A.¹ 

[1] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92617 USA

[2] Univ British Columbia, Fac Med, Vancouver, BC V6T 1Z3, Canada

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA USA

[4] Harvard Univ, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA USA

[5] Mind Res Network, Albuquerque, NM 87131 USA

[6] Univ New Mexico, Dept ECE, Albuquerque, NM 87131 USA

关键词: Schizophrenia;    Working memory;    Functional magnetic resonance imaging;    Partial least squares;    Multivariate analysis;    Neurocircuitry;   

DOI  :  10.1016/j.schres.2009.12.014

来源: Elsevier

【 摘 要 】

Background: Working memory studies in schizophrenia (SZ), using functional magnetic resonance imaging (fMRI) and univariate analyses, have led to observations of hypo- or hyperactivation of discrete Cortical regions and subsequent interpretations (e.g. neural inefficiencies). We employed a data-driven, multivariate analysis to identify the patterns of brain-behavior relationships in SZ during working memory. Methods: fMRI scans were collected from 13 SZ and 18 healthy control (HC) participants performing a modified Sternberg item recognition paradigm with three memory loads. We applied partial least squares analysis (PLS) to assess brain activation during the task both alone and with behavioral measures (accuracy and response time, RT) as covariates. Results: While the HC primary pattern was not affected by increasing load demands, SZ participants showed an exaggerated change in the Blood Oxygenation Level Dependent (BOLD) signal from the low to moderate memory load conditions and subsequent decrease in the greatest memory load, in frontal, motor, parietal and subcortical areas. With behavioral covariates, the separate groups identified distinct brain-behavior relationships and circuits. Increased activation of the middle temporal gyrus was associated with greater accuracy and faster RT only in SZ. Conclusions: The inverted U-shaped curves in the SZ BOLD signal in the same areas that show flat activation in the HC data indicate widespread neural inefficiency in working memory in SZ. While both groups performed the task with similar levels of accuracy, participants with schizophrenia show a compensatory network of different sub-regions of the prefrontal Cortex, parietal lobule. and the temporal gyri in this working memory task. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

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