Associations between circadian activity rhythms and functional brain abnormalities among euthymic bipolar patients: A preliminary study

JOURNAL OF AFFECTIVE DISORDERS

卷:164

Article

McKenna, Benjamin S.^1,2  Drummond, Sean P. A.^2,3,4  Eyler, Lisa T.^1,2 

[1] VA San Diego Healthcare Syst, Mental Illness Res Educ & Clin Ctr VISN 22, San Diego, CA 92161 USA

[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92161 USA

[3] VA San Diego Healthcare Syst, Psychol Serv, San Diego, CA 92161 USA

[4] VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA 92161 USA

关键词: Bipolar disorder;    Euthymic;    Sleep;    Circadian rhythms;    Working memory;    Functional magnetic resonance imaging;   

DOI  :  10.1016/j.jad.2014.04.034

来源: Elsevier

【 摘 要 】

Background: Working memory and underlying functional brain deficits have been observed in euthymic bipolar disorder (BD) patients, though there is heterogeneity in the degree of deficits. Sleep/circadian rhythm abnormalities are thought to be a core component of BD and may explain some of the heterogeneity in functional abnormalities. This preliminary study examined associations between sleep/circadian rhythm abnormalities and functional magnetic resonance imaging (fMRI) brain response on a working memory task among BD patients. Methods: Fourteen euthymic medicated BD patients wore an actigraph for 7 days before undergoing fMRI with a working memory task. Two matched healthy comparison (HC) groups were used (14 in each sample). One group completed the actigraphy portion and the other completed the fMRI portion of the study. Circadian activity rhythm and sleep variables were calculated and compared between BD and HC participants. Variables that significantly differed were used to examine the association between activity rhythms/sleep abnormalities and fMRI working memory brain response in anatomically defined regions. Results: Sleep efficiency and the rhythm robustness, mesor, and amplitude-to-width ratio were significantly abnormal in BD patients. Individual variability in all the sleep/circadian variables was significantly associated with the degree of abnormality of brain response in the dorsolateral prefrontal cortex and supramarginal gyri. Limitations: Small sample size and multiple comparison groups limit the interpretability of these findings. Conclusions: BD patients have abnormal activity rhythms and sleep efficiency, which are associated with abnormal working memory brain response. These preliminary findings support the notion that the sleep/circadian system is important in the functional brain deficits among BD patients. Published by Elsevier B.V.

【 授权许可】

Free