Impaired performance induced by fatigue may compromise safety in commercial aviation. Given the direct role flight attendants play in passenger safety, the U.S. Congress ordered a comprehensive examination of fatigue in cabin crew, including a field study of actual flight operations. This report provides an overview of the field study results, focusing on objective measures of sleep patterns and neurocognitive performance (Psychomotor Vigilance Test, PVT) over a 3-4 week period in 202 U.S.-based flight attendants of all seniority levels working for network, low-cost, and regional carriers embarking on domestic and international flight operations.