Schizophrenia moderates the relationship between white matter integrity and cognition

SCHIZOPHRENIA RESEARCH

卷:199

Article

Castro-de-Araujo, Luis F. S.^1,2  Allin, Mathew³  Picchioni, Marco M.⁴  Mcdonald, Colm⁵  Pantelis, Christos⁶  Kanaan, Richard A. A.^2,4 

[1] Minist Educ Brazil, CAPES Fdn, Brasilia, DF, Brazil

[2] Univ Melbourne, Austin Hlth, Dept Psychiat, Heidelberg, Vic, Australia

[3] Kings Coll London, Inst Psychiat, London, England

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[5] NUI, Galway, Ireland

[6] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia

关键词: Cognitive tests;    Linear models;    Statistical models;   

DOI  :  10.1016/j.schres.2018.03.033

来源: Elsevier

【 摘 要 】

Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities. (c) 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

【 授权许可】

Free