Advanced paternal age and risk of schizophrenia in offspring - Review of epidemiological findings and potential mechanisms

SCHIZOPHRENIA RESEARCH

卷:233

Review

Khachadourian, Vahe^1,2,3  Zaks, Nina¹  Lin, Emma^1,2  Reichenberg, Abraham^1,2,3,4  Janecka, Magdalena^1,2,3,5 

[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA

关键词: Advanced paternal age;    Paternal age;    Schizophrenia;    de novo mutations;    Delayed fatherhood;    Psychiatric epidemiology;   

DOI  :  10.1016/j.schres.2021.06.016

来源: Elsevier

【 摘 要 】

A large number of studies have examined the association between advanced paternal age (APA) and risk of schizophrenia in offspring. Here we present an overview of epidemiological studies on this subject published since 2000, and systematically summarize their methodologies and results. Next, we discuss evidence to elucidate the potential mechanisms contributing to the association between APA and offspring schizophrenia, considering paternal psychiatric morbidity and genetic liability, maternal factors, and findings from family design studies. We propose that multiple mechanisms, including causal and non-causal pathways, contribute to the observed relationship between APA and schizophrenia in offspring, and conclude by highlighting the need for multi-disciplinary studies in disentangling these complex, non-mutually exclusive mechanisms.

【 授权许可】

Free