Paternal age and psychiatric disorders: Findings from a Dutch population registry

SCHIZOPHRENIA RESEARCH

卷:129

Article

Buizer-Voskamp, Jacobine E.^2,3  Laan, Wijnand⁴  Staal, Wouter G.⁵  Hennekam, Eric A. M.⁶  Aukes, Maartje F.^2,4  Termorshuizen, Fabian⁴  Kahn, Rene S.²  Boks, Marco P. M.^2,4  Ophoff, Roel A.^1,2,3 

[1] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA 90095 USA

[2] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3584 CX Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Dept Med Genet, NL-3584 CG Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3584 CG Utrecht, Netherlands

[5] Univ Med Ctr Utrecht, Dept Child & Adolescent Psychiat, NL-3584 CX Utrecht, Netherlands

[6] Univ Med Ctr Utrecht, Dept Clin Genet, NL-3508 AB Utrecht, Netherlands

关键词: Bipolar disorder;    Child development disorders, pervasive;    Depressive disorder, major;    Paternal age;    Schizophrenia;   

DOI  :  10.1016/j.schres.2011.03.021

来源: Elsevier

【 摘 要 】

Background: We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population. Methods: In total, 14231 patients and 56924 matched controls were collected and analyzed for an association with paternal age by logistic regression. Results: ASD is significantly associated with increased paternal age: Older fathers >40 years of age have a 3.3 times increased odds of having a child with ASD compared to young fathers <20 years of age. SCZ has significant associations for fathers aged >35 years (OR = 1.27, 95% Confidence Interval: 1.05 and 1.53). For MOD, both younger and older fathers have increased odds. No association was found for BPD. Conclusions: The effects of paternal age as a risk factor are different for ASD and SCZ on one hand, and the affective disorders on the other hand. Different types of association might indicate different biological or psychosocial mechanisms. Late paternity (associated with predispositions to psychiatric disorders) seems the most probable explanation for the association with paternal age. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

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