Persistence, diagnostic specificity and genetic liability for context-processing deficits in schizophrenia

SCHIZOPHRENIA RESEARCH

卷:147

Article

Richard, Annette E.¹  Carter, Cameron S.^2,3  Cohen, Jonathan D.⁴  Cho, Raymond Y.¹ 

[1] Univ Pittsburgh, Dept Psychiat, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA

[2] Univ Calif Davis, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA

[3] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA

[4] Princeton Univ, Dept Psychol, Princeton, NJ 08540 USA

关键词: Cognition;    Attention;    Longitudinal study;    First-degree relative;    Diagnosis;    Endophenotype;   

DOI  :  10.1016/j.schres.2013.02.020

来源: Elsevier

【 摘 要 】

Context-processing deficits have been shown in schizophrenia during first-episode, medication-nave status, that persist after short-termantipsychotic treatment and also in first-degree relatives of individuals with schizophrenia. To confirm longer term persistence of deficits, we examined schizophrenia patients (n = 63) during first-episode, medication-nave status through to one-year follow-up, compared to healthy control (n = 83) and non-schizophrenia psychosis comparison (n = 47) groups, as well as unaffected first-degree relatives of individuals with schizophrenia (n = 31). Context-processing ability was assessed by performance on the AX-CPT (Continuous Performance Test) at baseline, 8 weeks, 6 months, and 1 year (relatives only at baseline). Reaction time, error rates and signal detection indices (d'-context) of context processing were analyzed. Linear discriminant analyses (LDA) on early timepoints (baseline, 8 weeks) were conducted to predict confirmatory diagnosis (schizophrenia vs. psychosis control) at 6 months. Schizophrenia patients showed evidence of impaired context-processing relative to both the healthy and psychosis comparator groups at baseline and continued through to 1 year. While context-processing impairments persisted in schizophrenia patients through one year, the impairments in psychosis controls, which were more modest at baseline, remitted at follow-up. First-degree relatives showed deficits that were intermediate between the schizophrenia and healthy control groups. LDA showed 67% classification rates for distinguishing schizophrenia from non-schizophrenia psychosis. The persistence, diagnostic specificity and association with genetic liability give support for context processing impairments serving as a cognitive endophenotype for schizophrenia and evaluation of context processing could contribute to diagnostic assessments. (c) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

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