Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus

SCHIZOPHRENIA RESEARCH

卷:184

Article

Gianfrancesco, Olympia¹  Warburton, Alix¹  Collier, David A.²  Bubb, Vivien J.¹  Quinn, John P.¹ 

[1] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England

[2] Eli Lilly & Co Ltd, Windlesham, Surrey, England

关键词: EU358092;    lncRNA;    microRNA-137;    Schizophrenia;   

DOI  :  10.1016/j.schres.2016.11.034

来源: Elsevier

【 摘 要 】

Genome-wide association studies (GWAS) have identified a locus on chromosome 1p21.3 to be highly associated with schizophrenia. A microRNA, MIR137, within this locus has been proposed as the gene causally associated with schizophrenia, due to its known role as a regulator of neuronal development and function. However, the involvement of other genes within this region, including DPYD (dihydropyrimidine dehydrogenase), is also plausible. In this communication, we describe a previously uncharacterised, brain-expressed RNA, EU358092, within the schizophrenia-associated region at 1p21.3. As we observed for MIR137, EU358092 expression was modulated in response to psychoactive drug treatment in the human SH-SY5Y neuroblastoma cell line. Bioinformatic analysis of publically available CNS expression data indicates that MIR137 and EU358092 are often co-expressed in vivo. A potential regulatory domain for expression of EU358092 is identified by bioinformatic analysis and its regulatory function is confirmed by reporter gene assays. These data suggest a potentially important role for EU358092 in the aetiology of schizophrenia, either individually or in combination with other genes at this locus. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

【 授权许可】

Free