MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia

NEUROSCIENCE LETTERS

卷:602

Article

Patel, Veena S.^1,2  Kelly, Sinead^3,4  Wright, Carrie^1,2,5  Gupta, Cota Navin^1,2  Arias-Vasquez, Alejandro⁶  Perrone-Bizzozero, Nora^5,7  Ehrlich, Stefan⁶  Wang, Lei¹³  Bustillo, Juan R.⁷  Morris, Derek^{3,4,8,9,10,11,12}  Corvin, Aiden^3,4  Cannon, Dara M.^8,9,10,11,12  McDonald, Colm^8,9,10,11,12  Donohoe, Gary^{3,4,8,9,10,11,12}  Calhoun, Vince D.^{1,2,5,7,14,15}  Turner, Jessica A.^1,2,16,17 

[1] Mind Res Network, Albuquerque, NM 87106 USA

[2] Lovelace Resp Res Inst, Albuquerque, NM 87106 USA

[3] Univ Dublin Trinity Coll, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 2, Ireland

[4] Univ Dublin Trinity Coll, Trinity Coll, Inst Neurosci, Dublin 2, Ireland

[5] Univ New Mexico, Sch Med, Dept Neurosci, Albuquerque, NM 87131 USA

[6] Tech Univ Dresden, Fac Med, Dept Child & Adolescent Psychiat, Translat Dev Neurosci Sect, D-01307 Dresden, Germany

[7] Univ New Mexico, Sch Med, Dept Psychiat, Albuquerque, NM 87131 USA

[8] Natl Univ Ireland, Clin Neuroimaging Lab, Galway, Ireland

[9] Natl Univ Ireland, Cognit Genet Grp, Dept Psychiat, Galway, Ireland

[10] Natl Univ Ireland, Dept Anat, Galway, Ireland

[11] Natl Univ Ireland, Dept Biochem, Galway, Ireland

[12] Natl Univ Ireland, Sch Psychol, Galway, Ireland

[13] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60614 USA

[14] Univ New Mexico, Dept Elect, Albuquerque, NM 87131 USA

[15] Univ New Mexico, Dept Comp Engn, Albuquerque, NM 87131 USA

[16] Georgia State Univ, Dept Psychol, POB 1150, Atlanta, GA 30302 USA

[17] Georgia State Univ, Dept Neurosci, Atlanta, GA 30302 USA

关键词: microRNA-137;    MIR137;    Schizophrenia;    Subcortical volume;    Corpus callosum;    Multi-site;   

DOI  :  10.1016/j.neulet.2015.06.039

来源: Elsevier

【 摘 要 】

Genome-wide association studies implicate the MIR137HG risk variant rsl 625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of individuals with schizophrenia and healthy controls (n=841). Although the volumes were overall reduced relative to healthy controls, for individuals with schizophrenia the homozygous MIR137HGrv risk genotype was associated with attenuated reduction of mid-posterior corpus callosum volume (p = 0.001), along with trend-level effects in the adjacent central and posterior corpus callosum. These findings are unique in the literature and remain robust after analysis in ethnically homogenous and single-scanner subsets of the larger sample. Thus, our study suggests that the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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