Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia

SCHIZOPHRENIA RESEARCH

卷:150

Article

Takayanagi, Mizuho^1,2  Wentz, Jacqueline^3,4  Takayanagi, Yoichiro⁵  Schretlen, David J.¹  Ceyhan, Elvan⁶  Wang, Lei⁷  Suzuki, Michio²  Sawa, Akira¹  Barta, Patrick E.^3,4  Ratnanather, J. Tilak^3,4  Cascella, Nicola G.⁸ 

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[2] Toyama Univ, Dept Neuropsychiat, Toyama 930, Japan

[3] Johns Hopkins Univ, Whitaker Biomed Engn Inst, Ctr Imaging Sci, Baltimore, MD USA

[4] Johns Hopkins Univ, Inst Computat Med, Whitaker Biomed Engn Inst, Baltimore, MD USA

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA

[6] Koc Univ, Dept Math, Istanbul, Turkey

[7] Northwestern Univ, Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA

[8] Sheppard Enoch Pratt Hosp, Neuropsychiat Program, Baltimore, MD USA

关键词: Schizophrenia;    Deficit schizophrenia;    Cortical thickness;    Anterior cingulate cortex;   

DOI  :  10.1016/j.schres.2013.07.036

来源: Elsevier

【 摘 要 】

Background: Patients with deficit schizophrenia (D-SZ) differ from patients with the non-deficit form of schizophrenia (ND-SZ) in several aspects such as risk factors, neurobiological correlates, treatment response and clinical outcome. It has been debated if brain morphology could differentiate D-SZ from ND-SZ. Anterior cingulate gyrus (ACG) region regulates cognitive and emotional processing and past studies reported structural changes in this region in patients with SZ. Methods: 1.5-T 3D MRI scans were obtained from 18 D-SZ patients, 30 ND-SZ patients and 82 healthy controls (HCs). We used FreeSurfer-initalized labeled cortical distance mapping (FSLCDM) to measure ACG gray matter volume, cortical thickness, and area of the gray/white interface. Furthermore, cortical thickness was compared among the 3 groups using the pooled labeled cortical distance mapping (LCDM) method. Results: The ACG cortex of the D-SZ group was thinner than the ND-SZ group. Pooled LCDM demonstrated that the ACG cortex was bilaterally thinner in both the ND-SZ group and the D-SZ group compared with the control group. The right ACG gray matter volume was significantly reduced in D-SZ patients as compared with healthy controls (p = 0.005 Conclusion: Our data suggest that qualitative, categorical differences in neuroanatomy may distinguish between deficit and non-deficit subtypes of schizophrenia. (C) 2013 Elsevier B. V. All rights reserved.

【 授权许可】

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