MEG-measured visually induced gamma-band oscillations in chronic schizophrenia: Evidence for impaired generation of rhythmic activity in ventral stream regions

SCHIZOPHRENIA RESEARCH

卷:176

Article

Grent-'t-Jong, Tineke⁶  Rivolta, Davide^1,2,3  Sauer, Andreas^1,2  Grube, Michael⁷  Singer, Wolf^1,2,4  Wibral, Michael⁵  Uhlhaas, Peter J.^1,2,6 

[1] Max Planck Inst Brain Res, Dept Neurophysiol, D-60528 Frankfurt, Germany

[2] Max Planck Gesell, Ernst Strungmann Inst ESI Neurosci Cooperat, D-60528 Frankfurt, Germany

[3] Univ East London, Sch Psychol, London, England

[4] Goethe Univ Frankfurt, FIAS, Frankfurt, Germany

[5] Goethe Univ Frankfurt, BIC, MEG Unit, D-60529 Frankfurt, Germany

[6] Univ Glasgow, Inst Neurosci & Psychol, Hillhead St 58, Glasgow G12 8QB, Lanark, Scotland

[7] Municipal Clin, Dept Psychiat & Psychotherapy Psychosomat, D-65929 Frankfurt, Germany

关键词: MEG;    Oscillations;    Schizophrenia;    Visual cortex;    Ventral stream;    E/I-balance;   

DOI  :  10.1016/j.schres.2016.06.003

来源: Elsevier

【 摘 要 】

Background: Gamma-band oscillations are prominently impaired in schizophrenia, but the nature of the deficit and relationship to perceptual processes is unclear. Methods: 16 patients with chronic schizophrenia (ScZ) and 16 age-matched healthy controls completed a visual paradigm while magnetoencephalographic (MEG) data was recorded. Participants had to detect randomly occurring stimulus acceleration while viewing a concentric moving grating. MEG data were analyzed for spectral power (1-100 Hz) at sensor-and source-level to examine the brain regions involved in aberrant rhythmic activity, and for contribution of differences in baseline activity towards the generation of low-and high-frequency power. Results: Our data show reduced gamma-band power at sensor level in schizophrenia patients during stimulus processing while alpha-band and baseline spectrum were intact. Differences in oscillatory activity correlated with reduced behavioral detection rates in the schizophrenia group and higher scores on the Cognitive Factor of the Positive and Negative Syndrome Scale. Source reconstruction revealed that extra-striate (fusiform/lingual gyrus), but not striate (cuneus), visual cortices contributed towards the reduced activity observed at sensor-level in ScZ patients. Importantly, differences in stimulus-related activity were not due to differences in baseline activity. Conclusions: Our findings highlight that MEG-measured high-frequency oscillations during visual processing can be robustly identified in ScZ. Our data further suggest impairments that involve dysfunctions in ventral stream processing and a failure to increase gamma-band activity in a task-context. Implications of these findings are discussed in the context of current theories of cortical-subcortical circuit dysfunctions and perceptual processing in ScZ. (C) 2016 Elsevier B.V. All rights reserved.

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