Long range temporal correlations (LRTCs) in MEG-data during emerging psychosis: Relationship to symptoms, medication-status and clinical trajectory

NeuroImage: Clinical

Tineke Grent-'t-Jong¹  J. Matias Palva²  Gabriela Cruz³  Peter J. Uhlhaas³  Satu Palva³  Rajeev Krishnadas³ 

[1] Corresponding author at: R 601, 62 Hillhead Street, School of Psychology, University of Glasgow, G12 8QB, United Kingdom.;Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany;Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom;

关键词: Schizophrenia;    Emerging-psychosis;    Magnetoencephalography;    Oscillations;    Longrange-temporal-correlations;    Biomarker;   

DOI  :  

来源: DOAJ

【 摘 要 】

Long-Range Temporal Correlations (LRTCs) index the capacity of the brain to optimally process information. Previous research has shown that patients with chronic schizophrenia present altered LRTCs at alpha and beta oscillations. However, it is currently unclear at which stage of schizophrenia aberrant LRTCs emerge. To address this question, we investigated LRTCs in resting-state magnetoencephalographic (MEG) recordings obtained from patients with affective disorders and substance abuse (clinically at low-risk of psychosis, CHR-N), patients at clinical high-risk of psychosis (CHR-P) (n = 115), as well as patients with a first episode (FEP) (n = 25). Matched healthy controls (n = 47) served as comparison group. LRTCs were obtained for frequencies from 4 to 40 Hz and correlated with clinical and neuropsychological data. In addition, we examined the relationship between LRTCs and transition to psychosis in CHR-P participants, and the relationship between LRTC and antipsychotic medication in FEP participants. Our results show that participants from the clinical groups have similar LRTCs to controls. In addition, LRTCs did not correlate with clinical and neurocognitive variables across participants nor did LRTCs predict transition to psychosis. Therefore, impaired LRTCs do not reflect a feature in the clinical trajectory of psychosis. Nevertheless, reduced LRTCs in the beta-band over posterior sensors of medicated FEP participants indicate that altered LRTCs may appear at the onset of the illness. Future studies are needed to elucidate the role of anti-psychotic medication in altered LRTCs.

【 授权许可】

Unknown