Abnormal visuomotor processing in schizophrenia

NeuroImage: Clinical

Nikolaos G. Christodoulou¹  Mohammad Z. Katshu¹  Michael Skelton¹  Elizabeth B. Liddle¹  Jyothika Kumar¹  Peter F. Liddle¹  Lena Palaniyappan¹  Fiesal Jan²  Ayaz Qureshi³  Emma L. Hall⁴  Peter G. Morris⁴  Siân E. Robson⁴  Matthew J. Brookes⁴ 

[1] Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham NG7 2TU, UK;Herschel Prins Centre, Glenfield Hospital, Leicestershire Partnership NHS Trust, Groby Road, Leicester LE3 9QP, UK;Kevin White Unit, Smithdown Health Park, Smithdown Road, Liverpool L15 2HE, UK;Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, UK;

关键词: Schizophrenia;    Magnetoencephalography;    Motor cortex;    Visual cortex;    Electrophysiological processes;   

DOI  :  10.1016/j.nicl.2015.08.005

来源: DOAJ

【 摘 要 】

Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post-movement beta rebound (PMBR)); whilst in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a self-paced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm.

【 授权许可】

Unknown