Hyperprolactinaemia in first episode psychosis - A longitudinal assessment

SCHIZOPHRENIA RESEARCH

卷:189

Article

Lally, John^1,2,3  Ajnakina, Olesya¹  Stubbs, Brendon^4,5  Williams, Hugh R.⁶  Colizzi, Marco¹  Carra, Elena^1,7  Fraietta, Sara⁸  Gardner-Sood, Poonam¹  Greenwood, Kathryn E.^9,10  Atakan, Zerrin¹  Mondelli, Valeria¹¹  Ismail, Khalida^11,12  Howes, Oliver¹  Taylor, David M.¹³  Smith, Shubalade¹⁴  Hopkins, David^12,15  Murray, Robin M.^1,16  Gaughran, Fiona^1,16 

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[2] Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Dublin, Ireland

[3] Univ Coll Dublin, Sch Med & Med Sci, St Vincents Hosp, Dept Psychiat, Dublin, Ireland

[4] Kings Coll London, Inst Psychiat, Hlth Serv & Populat Res Dept, De Crespigny Pk, London SE5 8AF, England

[5] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London SE5 8AZ, England

[6] South London & Maudsley NHS Fdn Trust, Lewisham Promoting Recovery Neighbourhood Team 3, London, England

[7] Univ Modena & Reggio Emilia, Modena, MO, Italy

[8] Villa Letizia, Psychiat Rehabil Ctr, Rome, Italy

[9] Univ Sussex, Sch Psychol, Brighton, E Sussex, England

[10] Sussex Partnership NHS Fdn Trust, Early Intervent Psychosis Serv, Worthing, W Sussex, England

[11] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Psychol Med, London, England

[12] Kings Coll Hosp NHS Fdn Trust, London, England

[13] South London & Maudsley NHS Fdn Trust, Dept Pharm, London, England

[14] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, London, England

[15] Kings Hlth Partners, Inst Diabet Endocrinol & Obes, London, England

[16] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England

关键词: Prolactin;    Hyperprolactinaemia;    First episode psychosis (FEP);    Schizophrenia;    Antipsychotics;    Stress;   

DOI  :  10.1016/j.schres.2017.07.037

来源: Elsevier

【 摘 要 】

Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12 months later. HPL was defined as a serum prolactin level >410 mIU/L (similar to 19.3 ng/ml) for males, and a serum prolactin level >510 mIU/L (similar to 24.1 ng/ml) for females. From a total of 174 people with serum prolactin measurements at study recruitment, 43% (n = 74) had HPL, whilst 27% (n = 21/78) and 27% (n= 26/95) had HPL at 3 and 12 months respectively. We observed higher serum prolactin levels in females versus males (p < 0.001), and in antipsychotic treated (n = 68) versus antipsychotic naive patients (p < 0.0001). Prolactin levels were consistently raised in FEP patients taking risperidone, amisulpride and FGAs compared to other antipsychotics. No significant relationship was observed between perceived stress scores (beta = 7.13, t = 0.21, df = 11, p = 0.0.84 95% CI - 72.91-87.16), or objective life stressors (beta = - 21.74, t = -0.31, df = 8, p = 0.77 95% CI - 218.57-175.09) and serum prolactin. Our study found elevated rates of HPL over the course of the first 12 months of illness. We found no evidence to support the notion that stress is related to elevated serum prolactin at the onset of psychosis. (C) 2017 Elsevier B.V. All rights reserved.

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