No alteration of leukocyte telomere length in first episode psychosis

PSYCHIATRY RESEARCH

卷:301

Article

Schurhoff, Franck¹  Corfdir, Cecile¹  Pignon, Baptiste¹  Lajnef, Mohamed¹  Richard, Jean-Romain¹  Marcos, Elisabeth²  Pelissolo, Antoine¹  Leboyer, Marion¹  Adnot, Serge²  Jamain, Stephane¹  Szoke, Andrei¹ 

[1] Univ Paris Est Creteil UPEC, Hop Univ H Mondor, AP HP, DMU IMPACT,INSERM,IMRB,Translat Neuropsychiat,Fdn, F-94010 Creteil, France

[2] Hop Henri Mondor, AP HP, FHU SENEC, INSERM U955,Dept Physiol Explorat Fonct, F-94000 Creteil, France

关键词: First episode psychosis (FEP);    Schizophrenia;    Telomere;   

DOI  :  10.1016/j.psychres.2021.113941

来源: Elsevier

【 摘 要 】

Both shorter telomeres and schizophrenia have been associated with a decrease in life expectancy. Furthermore, several studies found a shorter telomere length (TL) in schizophrenia. Understanding whether or not telomere shortening is directly related to pathophysiology of schizophrenia or is a consequence of a cumulative exposure to chronic stress is of major importance. Comparing the TL of subjects at the very beginning of the disease (FEP) and control subjects could help to decide between these two hypotheses. The aim of the present study was to compare TL between FEP subjects (N=91) and controls (N=137). After accounting for multiple potential confounders, no significant association was observed between FEP and TL. Our result is consistent with the hypothesis that psycho-social stress / adversities and stressful situations in people with schizophrenia affect TL rather than that telomere erosion contributes to the development of this disorder.

【 授权许可】

Free