Duration of untreated psychosis and cognitive functioning

SCHIZOPHRENIA RESEARCH

卷:145

Article

Rapp, Charlotte¹  Studerus, Erich¹  Bugra, Hilal¹  Aston, Jacqueline¹  Tamagni, Corinne¹  Walter, Anna¹  Pflueger, Marlon¹  Borgwardt, Stefan¹  Riecher-Roessler, Anita¹ 

[1] Univ Basel, Psychiat Clin, Univ Basel Hosp, CH-4031 Basel, Switzerland

关键词: First episode psychosis (FEP);    At risk mental state (ARMS);    Neuropsychology;    Cognitive deterioration;    Duration of untreated illness;    Duration of untreated psychosis;   

DOI  :  10.1016/j.schres.2012.12.016

来源: Elsevier

【 摘 要 】

Background: Studies examining the influence of duration of untreated psychosis (DUP) or duration of untreated illness (DUI) on cognition vary with regard to results and methods. This study is the first in this field to include an at risk mental state with later transition to psychosis (ARMS-T) sample and to analyse how the DUI relates to their cognitive functioning. Because methodological operationalization of cognitive functioning in previous studies is highly heterogeneous, we aimed to compare different approaches. Method: 60 first episode psychosis (FEP) patients and 24 ARMS-T patients were examined. Associations between DUP, DUI and neurocognitive performance were tested by three different operationalizations of cognition: as the raw outcome measure of different neuropsychological tests, as outcome scores which were normed on a sample of 75 healthy participants, and as the deterioration index (DI). Results: There were no significant correlations between DUP or DUI and outcome of neuropsychological tests in both normed and raw scores. When adjusted for covariates, DUP and DUI also did not significantly predict any cognitive performance. There was no significant relationship between DUP or DUI and the DI index. However, longer DUP and DUI were significantly associated with stronger negative symptoms. Conclusions: This study could not confirm an association between duration of untreated psychosis or duration of untreated illness and neurocognitive performance in the ARMS-T and FEP samples. This could be because schizophrenic psychoses are neurodevelopmental disorders in which most cognitive deficits exist long before the onset of psychiatric symptoms. (C) 2013 Elsevier B. V. All rights reserved.

【 授权许可】

Free