Management of a microprolactinoma with aripiprazole in a woman with cabergoline-induced mania

Endocrinology, Diabetes & Metabolism Case Reports

article

Lisa Burback¹ 

[1]Alberta Hospital Edmonton, Addiction and Mental Health Program, Alberta Health Services, 17480 Fort Road, Post Office Box 307

关键词: Adult;    Female;    White;    Canada;    Pituitary;    Pituitary;    Prolactin;    Microprolactinoma;    Pituitary carcinoma;    Hyperprolactinaemia;    Mania;    Psychosis;    Mood changes/swings;    Depression;    Headache;    Hallucination;    Galactorrhoea;    Amenorrhoea;    Agitation;    Anorexia;    Hypersomnia;    MRI;    Prolactin;    Dopamine agonists;    Cabergoline;    Olanzapine;    Antipsychotics;    General practice;    Neurology;    Psychology/Psychiatry;    Novel treatment;    November;    2015;   

DOI  :  10.1530/EDM-15-0100

学科分类：血液学

来源: Bioscientifica Ltd.

【 摘 要 】

A previously healthy 32-year-old woman developed cyclical mood swings after being prescribed cabergoline for apituitary microprolactinoma. These mood swings persisted for over 2 years, at which point she developed an acute manicepisode with psychotic features and was admitted to a psychiatry unit. Cabergoline was discontinued and replacedwith aripiprazole 10 mg/day. Her manic episode quickly resolved, and she was discharged within 6 days of admission.The aripiprazole suppressed her prolactin levels for over 18 months of follow-up, even after the dose was lowered to 2 mg/day.There was no significant change in tumor size over 15 months and treatment was well tolerated. However, after 9 months oftaking 2 mg aripiprazole, she developed brief manic symptoms, and the dose was returned to 10 mg daily, with good effect.

【 授权许可】

CC BY-NC-ND