Removal of retained electrospinning solvent prolongs drug release from electrospun PLLA fibers

POLYMER

卷:123

Article

D'Amato, Anthony R.^1,2  Schaub, Nicholas J.³  Cardenas, Jesus M.^1,2  Fiumara, Andrew S.^1,2  Troiano, Paul M.^1,2  Fischetti, Andrea¹  Gilbert, Ryan J.^1,2 

[1] Rensselaer Polytech Inst, Dept Biomed Engn, 110 8th St, Troy, NY 12180 USA

[2] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA

[3] NIST, 100 Bur Dr, Gaithersburg, MD 20899 USA

关键词: Drug delivery;    Biomaterials;    Electrospun fibers;   

DOI  :  10.1016/j.polymer.2017.07.008

来源: Elsevier

【 摘 要 】

A major challenge in developing drug-releasing electrospun nanofibers is obtaining long-term drug release over many weeks with no burst release of drug. Here, we present new methods capable of prolonging the diffusive release of small molecule drugs from electrospun poly-L-lactic acid ( PLLA) nanofibers. The methods focus on removal of retained electrospinning solvent through fiber heating, maintaining fibers in a laboratory setting, or a combination of these methods. These post-fabrication methods altered the release characteristics of a model small molecule drug, 6-aminonicotinamide (6AN), from PLLA fibers. Specifically, untreated fibers released 6AN over 9 days, and fibers that underwent a combined treatment of maintenance in a laboratory setting and heating released 6AN over 44 days. The unique and simple method presented here prolongs diffusive release of a small molecule drug from electrospun fibers and has potential to assist in lengthening small molecule drug release from a variety of polymeric nanomaterials. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free