Synaptic functions of endocannabinoid signaling in health and disease

NEUROPHARMACOLOGY

卷:124

Review

Araque, Alfonso¹  Castillo, Pablo E.²  Manzoni, Olivier J.^3,4,5  Tonini, Raffaella⁶ 

[1] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA

[2] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, New York, NY 10461 USA

[3] Inst Natl Sante & Rech Med, U901, Marseille, France

[4] Univ Mediterranee, UMR S901, Aix Marseille Marseille, Marseille, France

[5] INMED Marseille, Marseille, France

[6] Ist Italiano Tecnol, Neurosci & Brain Technol Dept, Genoa, Italy

关键词: Endocannabinoids;    Synaptic plasticity;    Hippocampus;    Striatum;    Prefrontal cortex;    Astrocytes;   

DOI  :  10.1016/j.neuropharm.2017.06.017

来源: Elsevier

【 摘 要 】

Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of synaptic transmission and plasticity. They are synthetized on demand following physiological and/or pathological stimuli. Once released from postsynaptic neurons, eCBs typically act as retrograde messengers to activate presynaptic type 1 cannabinoid receptors (CB1) and induce short- or long-term depression of neurotransmitter release. Besides this canonical mechanism of action, recent findings have revealed a number of less conventional mechanisms by which eCBs regulate neural activity and synaptic function, suggesting that eCB-mediated plasticity is mechanistically more diverse than anticipated. These mechanisms include non-retrograde signaling, signaling via astrocytes, participation in long-term potentiation, and the involvement of mitochondria] CBI. Focusing on paradigmatic brain areas, such as hippocampus, striatum, and neocortex, we review typical and novel signaling mechanisms, and discuss the functional implications in normal brain function and brain diseases. In summary, eCB signaling may lead to different forms of synaptic plasticity through activation of a plethora of mechanisms, which provide further complexity to the functional consequences of eCB signaling. This article is part of the Special Issue entitled A New Dawn in Cannabinoid Neurobiology. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free