Neurocircuitry of drug reward

NEUROPHARMACOLOGY

卷:76

Review

Ikemoto, Satoshi¹  Bonci, Antonello^1,2,3 

[1] NIDA, Intramural Res Program, NIH, US Dept Hlth & Human Serv, Baltimore, MD 21224 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94110 USA

[3] Johns Hopkins Sch Med, Solomon H Snyder Neurosci Inst, Baltimore, MD 21205 USA

关键词: Drug reward;    Motivation;    Emotion;    Dopamine;    Ventral tegmental area;    Ventral striatum;    Supramammillary nucleus;    Median raphe nucleus;   

DOI  :  10.1016/j.neuropharm.2013.04.031

来源: Elsevier

【 摘 要 】

In recent years, neuroscientists have produced profound conceptual and mechanistic advances on the neurocircuitry of reward and substance use disorders. Here, we will provide a brief review of intracranial drug self-administration and optogenetic self-stimulation studies that identified brain regions and neurotransmitter systems involved in drug- and reward-related behaviors. Also discussed is a theoretical framework that helps to understand the functional properties of the circuitry involved in these behaviors. The circuitry appears to be homeostatically regulated and mediate anticipatory processes that regulate behavioral interaction with the environment in response to salient stimuli. That is, abused drugs or, at least, some may act on basic motivation and mood processes, regulating behavior-environment interaction. Optogenetics and related technologies have begun to uncover detailed circuit mechanisms linking key brain regions in which abused drugs act for rewarding effects. Published by Elsevier Ltd.

【 授权许可】

Free