Repeated cocaine exposure induces sensitization of ultrasonic vocalization in rats

NEUROSCIENCE LETTERS

卷:453

Article

Mu, Ping¹  Fuchs, Thomas¹  Saal, Daniel B.¹  Sorg, Barbara A.¹  Dong, Yan¹  Panksepp, Jaak¹ 

[1] Washington State Univ, Program Neurosci, Dept VCAPP, Pullman, WA 99164 USA

关键词: Locomotor sensitization;    Ultrasonic vocalization;    Emotion;    Motivation;    Addiction;    Cocaine;   

DOI  :  10.1016/j.neulet.2009.02.007

来源: Elsevier

【 摘 要 】

Ultrasonic vocalization at 55 kHz (55 kHz-USVs) by rodents has been proposed to be a behavioral manifestation of affectively positive incentive motivation. To examine the extent to which 55 kHz-USV emissions correlate with cocaine-induced locomotor activity, we measured cocaine-induced 55 kHz-USVs and their relationship to cocaine-induced locomotor sensitization in rats. We demonstrate that similar to locomotor responses, 55 kHz-USVs are also sensitized by exposure to cocaine. Furthermore, we show that the magnitude of cocaine-induced 55 kHz-USV sensitization is positively correlated with that of locomotor sensitization. Moreover, we demonstrate that rats selectively bred for high rates of 55 kHz-USVs exhibit higher levels of cocaine-induced 55 kHz-USV sensitization than animals selectively bred for low levels of 55 kHz USVs. These results suggest that the neural circuits underlying 55 kHz-USV, which may directly reflect affective experience/motivation, can be sensitized by cocaine in a way that resembles locomotor sensitization. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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