Lipid rafts, cholesterol, and the brain

NEUROPHARMACOLOGY

卷:55

Review

Korade, Zeljka^1,2  Kenworthy, Anne K.^3,4 

[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Vanderbilt Kennedy Ctr, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Sch Med, Dept Cell & Dev Biol, Nashville, TN 37232 USA

关键词: Lipid rafts;    Cholesterol;    Growth factors (neurotrophins);    Brain;    Myelin;    Neurodegenerative disorders;   

DOI  :  10.1016/j.neuropharm.2008.02.019

来源: Elsevier

【 摘 要 】

Lipid rafts are specialized membrane microdomains that serve as organizing centers for assembly of signaling molecules. influence membrane fluidity and trafficking of membrane proteins, and regulate different cellular processes such as neurotransmission and receptor trafficking. In this article, we provide an overview of Current methods for Studying lipid rafts and models for how lipid rafts might form and function. Next, we propose a potential mechanism for regulating lipid rafts in the brain via local control of cholesterol biosynthesis by neurotrophins and their receptors. Finally, we discuss evidence that altered cholesterol metabolism and/or lipid rafts play a critical role in the pathophysiology of multiple CNS disorders, including Smith-Lemli-Opitz syndrome, Huntington's, Alzheimer's, and Niemann-Pick Type C diseases. (C) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

Free