NMDARs in prefrontal cortex - Regulation of synaptic transmission and plasticity

NEUROPHARMACOLOGY

卷:192

Review

Banks, Paul J.¹  Bashir, Zafar, I¹ 

[1] Univ Bristol, Sch Physiol Pharmacol & Neurosci, Biomed Sci Bldg, Bristol BS8 1TD, Avon, England

关键词: Prefrontal cortex;    NMDA receptors;    Synaptic plasticity;    Learning and memory;    Hippocampus;    Nucleus reuniens;   

DOI  :  10.1016/j.neuropharm.2021.108614

来源: Elsevier

【 摘 要 】

A Summary: In this review we consider the various roles played by N-methyl-D-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC

【 授权许可】

Free