New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats

NEUROPHARMACOLOGY

卷:62

Article

Bussey, T. J.^1,2,3  Holmes, A.⁴  Lyon, L.^1,2,3  Mar, A. C.^1,2,3  McAllister, K. A. L.^1,2,3  Nithianantharajah, J.^2,3,5  Oomen, C. A.^1,2,3  Saksida, L. M.^1,2,3 

[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

[2] Univ Cambridge, MRC, Cambridge CB2 3EB, England

[3] Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[4] NIAAA, NIH, Rockville, MD 20852 USA

[5] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

关键词: Attention;    Working memory;    Pattern separation;    PCP;    Paired associate learning;    Neurogenesis;    Visual discrimination;    Extinction;    Autoshaping;    Cognition;   

DOI  :  10.1016/j.neuropharm.2011.04.011

来源: Elsevier

【 摘 要 】

We describe a touchscreen method that satisfies a proposed 'wish-list' of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. These tests can be used to study reward learning, memory, perceptual discrimination, object-place associative learning, attention, impulsivity, compulsivity, extinction, simple Pavlovian conditioning, and other constructs. The tests can be deployed using a 'flexible battery' approach to establish a cognitive profile for a particular mouse or rat model. We have found these tests to be capable of detecting not just impairments in function, but enhancements as well, which is essential for testing putative cognitive therapies. New tests are being continuously developed, many of which may prove particularly valuable for schizophrenia research. This article is part of a Special Issue entitled 'Schizophrenia'. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free