Addiction science: Uncovering neurobiological complexity

NEUROPHARMACOLOGY

卷:76

Review

Volkow, N. D.¹  Baler, R. D.¹ 

[1] NIDA, NIH, 6001 Execut Blvd,Room 5274, Bethesda, MD 20892 USA

关键词: Addiction;    SUD;    Dopamine;    Nucleus accumbens;    Brain imaging;    Reward;   

DOI  :  10.1016/j.neuropharm.2013.05.007

来源: Elsevier

【 摘 要 】

Until very recently addiction-research was limited by existing tools and strategies that were inadequate for studying the inherent complexity at each of the different phenomenological levels. However, powerful new tools (e.g., optogenetics and designer drug receptors) and high throughput protocols are starting to give researchers the potential to systematically interrogate all genes, epigenetic marks, and neuronal circuits. These advances, combined with imaging technologies (both for preclinical and clinical studies) and a paradigm shift toward open access have spurred an unlimited growth of datasets transforming the way we investigate the neurobiology of substance use disorders (SUD) and the factors that modulate risk and resilience. Published by Elsevier Ltd.

【 授权许可】

Free