Upregulation of acid-sensing ion channel 1 protein expression by chronic administration of cocaine in the mouse striatum in vivo

NEUROSCIENCE LETTERS

卷:459

Article

Zhang, Guo-Chi¹  Mao, Li-Min¹  Wang, John Q.¹  Chu, Xiang-Ping¹ 

[1] Univ Missouri, Sch Med, Dept Basic Med Sci, Kansas City, MO 64108 USA

关键词: ASICs;    Caudate;    Nucleus accumbens;    Cortex;    Hippocampus;    Addiction;    Dopamine;    Drug abuse;   

DOI  :  10.1016/j.neulet.2009.05.013

来源: Elsevier

【 摘 要 】

Acid-sensing ion channels (ASICs) are ligand-gated cation channels activated by a drop in extracellular pH. They are enriched in the mammalian brain with a high synaptic density. Accumulating evidence suggests that ASIC1 contributes to synaptic activity related to learning/memory and fear conditioning, and also plays critical roles in neurodegenerative diseases. In this study, we explored the effect of the psychostimulant. cocaine, on protein expression of ASICs in the mouse forebrain in vivo. We found that chronic systemic injection of cocaine (20 mg/kg, once daily for 5 consecutive days; 14 days of withdrawal) increased ASIC1, but not ASIC2, protein levels in the striatum, including the dorsal (caudate putamen) and the ventral (nucleus accumbens) striatum. No significant changes in ASIC1 or 2 protein levels in the median prefrontal cortex and the hippocampus were observed following the chronic cocaine administration. These data demonstrate that chronic cocaine exposure can upregulate ASIC expression in the striatum in a subunit-selective manner. Published by Elsevier Ireland Ltd.

【 授权许可】

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