Cholinergic forebrain degeneration in the APPswe/PSI1ΔE9 transgenic mouse

NEUROBIOLOGY OF DISEASE

卷:28

Article

Perez, Sylvia E. ; Dar, Saleem ; Ikonomovic, Milos D. ; DeKosky, Steven T. ; Mufson, Elliott J.

关键词: Alzheimer's disease;    amyloid;    forebrain;    transgenics;    acetylcholine;    ChAT activity;    AChE;    stereology;    interneurons;    degeneration;   

DOI  :  10.1016/j.nbd.2007.06.015

来源: Elsevier

【 摘 要 】

The impact of Delta beta deposition upon cholinergic intrinsic cortical and striatal, as well as basal forebrain long projection neuronal systems was qualitatively and quantitatively evaluated in young (2-6 months) and middle-aged (10-16 months) APPswe/PS1 Delta E9 transgenic (tg) mice. Cholinergic neuritic swellings occurred as early as 2-3 months of age in the cortex and hippocampus and 5-6 months in the striatum of tg mice. However, cholinergic neuron number or choline acetyltransferase (ChAT) optical density measurements remained unchanged in the forebrain structures with age in APPswe/PS1 Delta E9 tg mice. ChAT enzyme activity decreased significantly in the cortex and hippocampus of middle-aged tg mice. These results suggest that A 0 deposition has age-dependent effects on cortical and hippocampal ChAT fiber networks and enzyme activity, but does not impact the survival of cholinergic intrinsic or long projection forebrain neurons in APPswe/ PS1 Delta E9 tg mice. (C) 2007 Elsevier Inc. All rights reserved.

【 授权许可】

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