Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease

NEUROBIOLOGY OF DISEASE

卷:26

Article

Boska, Michael D. ; Hasan, Khader M. ; Kibuule, Danette ; Banerjee, Rebecca ; McIntyre, Erin ; Nelson, Jay A. ; Hahn, Theresa ; Gendelman, Howard E. ; Mosley, R. Lee

关键词: Parkinson's disease;    diffusion tensor imaging;    1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine;    MPTP;    substantia nigra;    striatum;    dopaminergic neurons;   

DOI  :  10.1016/j.nbd.2007.02.010

来源: Elsevier

【 摘 要 】

Early diagnosis of Parkinson's disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect >50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion (p<0.005) and decreased fractional anisotropy (P<0.03) in the substantia nigra (SN) of 5- to 7-day MPTP-treated animals when compared to saline controls. Transverse diffusivity demonstrated the most significant differences (p <= 0.002) and correlated with the numbers of SN dopaminergic neurons (r=-0.75, p=0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration. (c) 2007 Elsevier Inc. All rights reserved.

【 授权许可】

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