ACTIVITY PATTERNS IN A PARKINSON'S MONKEY MODEL

Parkinson;Parkinson"s;MPTP;Actigraphy;Biostatistics

Leroux, AndrewCrainiceanu, Ciprian ;

Johns Hopkins University

关键词: Parkinson;    Parkinson";    s;    MPTP;    Actigraphy;    Biostatistics;   

Others  :  https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/60374/LEROUX-THESIS-2015.pdf?sequence=4&isAllowed=y

瑞士|英语

来源: JOHNS HOPKINS DSpace Repository

【 摘 要 】

In a study conducted at the University of Pittsburgh, 35 female rhesus monkeys were exposed to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in an effort to establish a plausible animal model for Parkinson;;s disease progression and treatment using neurotrophic factors. In addition to standard clinical measurements of Parkinson;;s severity, actigraphy devices recording minute level activity weret to each of the monkeys. This thesis primarily aims to understand how activity patterns in healthy subjectscan predict their susceptibility to developing Parkinson;;s-like symptoms as a resultof MPTP exposure. Secondarily, we show how subjects respond to neurotrophic factorsin terms of both subjects;; activity and through standard clinical metrics.