Detrimental impacts of mixed-ion radiation on nervous system function

NEUROBIOLOGY OF DISEASE

卷:151

Article

Klein, Peter M.¹  Parihar, Vipan K.²  Szabo, Gergely G.¹  Zoldi, Miklos³  Angulo, Maria C.²  Allen, Barrett D.²  Amin, Amal N.²  Nguyen, Quynh-Anh¹  Katona, Istvan^3,4  Baulch, Janet E.²  Limoli, Charles L.²  Soltesz, Ivan^1,5 

[1] Stanford Univ, Dept Neurosurg, Palo Alto, CA 94305 USA

[2] Univ Calif Irvine, Dept Radiat Oncol, Irvine, CA 92697 USA

[3] Hungarian Acad Sci, Inst Expt Med, Momentum Lab Mol Neurobiol, H-1083 Budapest, Hungary

[4] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA

[5] Stanford Univ, Dept Neurol & Neurol Sci, Palo Alto, CA 94305 USA

关键词: Space radiation;    Electrophysiology;    Sharp wave-ripple;    Hippocampus;    Cognitive dysfunction;   

DOI  :  10.1016/j.nbd.2021.105252

来源: Elsevier

【 摘 要 】

Galactic cosmic radiation (GCR), composed of highly energetic and fully ionized atomic nuclei, produces diverse deleterious effects on the body. In researching the neurological risks of GCR exposures, including during human spaceflight, various ground-based single-ion GCR irradiation paradigms induce differential disruptions of cellular activity and overall behavior. However, it remains less clear how irradiation comprising a mix of multiple ions, more accurately recapitulating the space GCR environment, impacts the central nervous system. We therefore examined how mixed-ion GCR irradiation (two similar 5-6 beam combinations of protons, helium, oxygen, silicon and iron ions) influenced neuronal connectivity, functional generation of activity within neural circuits and cognitive behavior in mice. In electrophysiological recordings we find that space-relevant doses of mixed-ion GCR preferentially alter hippocampal inhibitory neurotransmission and produce related disruptions in the local field potentials of hippocampal oscillations. Such underlying perturbation in hippocampal network activity correspond with perturbed learning, memory and anxiety behavior.