Detrimental impacts of mixed-ion radiation on nervous system function

Neurobiology of Disease

Vipan K. Parihar¹  Charles L. Limoli²  István Katona³  Peter M. Klein³  Miklós Zöldi³  Gergely G. Szabo⁴  Quynh-Anh Nguyen⁴  Barrett D. Allen⁴  Ivan Soltesz⁴  Amal N. Amin⁴  Janet E. Baulch⁵  Maria C. Angulo⁵ 

[1] Corresponding author at: 1201 Welch Rd, Palo Alto, CA 94305, United States of America.;Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, United States of America;Department of Neurosurgery, Stanford University, Palo Alto, CA 94305, United States of America;Department of Radiation Oncology, University of California, Irvine, CA 92697, United States of America;Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary;

关键词: Space radiation;    Electrophysiology;    Sharp wave-ripple;    Hippocampus;    Cognitive dysfunction;   

DOI  :  

来源: DOAJ

【 摘 要 】

Galactic cosmic radiation (GCR), composed of highly energetic and fully ionized atomic nuclei, produces diverse deleterious effects on the body. In researching the neurological risks of GCR exposures, including during human spaceflight, various ground-based single-ion GCR irradiation paradigms induce differential disruptions of cellular activity and overall behavior. However, it remains less clear how irradiation comprising a mix of multiple ions, more accurately recapitulating the space GCR environment, impacts the central nervous system. We therefore examined how mixed-ion GCR irradiation (two similar 5-6 beam combinations of protons, helium, oxygen, silicon and iron ions) influenced neuronal connectivity, functional generation of activity within neural circuits and cognitive behavior in mice. In electrophysiological recordings we find that space-relevant doses of mixed-ion GCR preferentially alter hippocampal inhibitory neurotransmission and produce related disruptions in the local field potentials of hippocampal oscillations. Such underlying perturbation in hippocampal network activity correspond with perturbed learning, memory and anxiety behavior.

【 授权许可】

Unknown