Microglia and astrocyte dysfunction in parkinson's disease

NEUROBIOLOGY OF DISEASE

卷:144

Review

Kam, Tae-In^1,2,3  Hinkle, Jared T.⁴  Dawson, Ted M.^1,2,3,4,5  Dawson, Valina L.^1,2,3,4,6 

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Neuroregenerat Program, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Stem Cell Program, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21205 USA

关键词: Microglia;    Astrocyte;    Glia;    Neuroinflammation;    Neurodegeneration;    Parkinson's disease;    Neurodegenerative disease;   

DOI  :  10.1016/j.nbd.2020.105028

来源: Elsevier

【 摘 要 】

While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.