Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease

NEUROBIOLOGY OF DISEASE

卷:72

Review

Malnar, Martina¹  Hecimovic, Silva¹  Mattsson, Niklas^2,3,4  Zetterberg, Henrik^2,5 

[1] Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia

[2] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Clin Neurochem Lab,Inst Neurosci & Physiol, Gothenburg, Sweden

[3] San Francisco VA Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[5] UCL Inst Neurol, London WC1N 3BG, England

关键词: Alzheimer's disease;    Amyloid-beta;    Niemann-Pick type C disease;    NPC1;    Tau;    Cholesterol;    Lipids;   

DOI  :  10.1016/j.nbd.2014.05.033

来源: Elsevier

【 摘 要 】

Alzheimer's disease (AD) and Niemann-Pick type C (NPC) disease are progressive neurodegenerative diseases with very different epidemiology and etiology. AD is a common cause of dementia with a complex polyfactorial etiology, including both genetic and environmental risk factors, while NPC is a very rare autosomal recessive disease. However, the diseases share some disease-related molecular pathways, including abnormal cholesterol metabolism, and involvement of amyloid-beta (A beta) and tau pathology. Here we review recent studies on these pathological traits, focusing on studies of A beta and tau pathology in NPC, and the importance of the NPC1 gene in AD. Further studies of similarities and differences between AD and NPC may be useful to increase the understanding of both these devastating neurological diseases. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free