Cognition or genetics? Predicting Alzheimer's disease with practice effects, APOE genotype, and brain metabolism

NEUROBIOLOGY OF AGING

卷:71

Article

Oltra-Cucarella, Javier¹  Sanchez-SanSegundo, Miriam¹  Ferrer-Cascales, Rosario¹ 

[1] Univ Alicante Spain, Dept Hlth Psychol, Campus San Vicente Del Raspeig S-N, Alicante 03690, Spain

关键词: Alzheimer's disease;    Cognitive impairment;    Dementia;    Mild cognitive impairment;    Neurodegenerative;    Practice effects;   

DOI  :  10.1016/j.neurobiolaging.2018.08.004

来源: Elsevier

【 摘 要 】

As practice effects are common in neuropsychological assessment, this study analyzed their utility to identify individuals with amnestic mild cognitive impairment (aMCI) at the greatest risk for Alzheimer's disease (AD-risk) and compared practice effects with APOE and brain metabolism biomarkers. We regressed Auditory Verbal Learning Test delayed recall (AVLT-DR) at 6 months on baseline AVLT-DR scores in 394 individuals with normal cognition from the Alzheimer's Disease Neuroimaging Initiative database and dichotomized 816 individuals with aMCI as showing practice effect or not showing practice effects (PE-) when the discrepancy between observed and predicted scores was found in less than 10%, 7%, and 5% of normal cognition. Cox regressions analyzed the AD-risk at 6 years. More than 60% of aMCI were showing practice effects. Controlling for age, sex, education, and baseline Mini-Mental State Examination and AVLT-DR scores, the AD-risk was associated with PE- [hazard ratio (HR) = 1.93], lower brain metabolism (HR = 0.95), and APOE genotype (HR = 1.92), with narrower risk estimates for PE-. The lack of practice effects during a 6-month period might be as precise as biomarkers for predicting the 6-year AD-risk. (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

Free