Serum leptin level and cognition in the elderly: Findings from the Health ABC Study

NEUROBIOLOGY OF AGING

卷:30

Article

Holden, Karen F.¹  Lindquist, Karla²  Tylavsky, Frances A.³  Rosano, Caterina⁴  Harris, Tamara B.⁵  Yaffe, Kristine^1,6,7,8 

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[3] Univ Tennessee, Dept Prevent Med, Memphis, TN 38163 USA

[4] Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15213 USA

[5] NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD 20892 USA

[6] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[7] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA

[8] San Francisco VA Med Ctr, San Francisco, CA 94121 USA

关键词: Leptin;    Cognition;    Learning;    Memory;    Elderly;    Aging;    Dementia;    Alzheimer's disease;    Obesity;    Hyperleptinemia;    Leptin resistance;    Metabolic syndrome;   

DOI  :  10.1016/j.neurobiolaging.2007.11.024

来源: Elsevier

【 摘 要 】

Leptin is a peptide hormone secreted by adipocytes. It has been shown to modulate production and clearance of amyloid beta (A beta) in rodent models. We sought to determine if serum leptin was associated with cognitive decline in the elderly. We studied 2871 well-functioning elders, aged 70-79, who were enrolled in a prospective study. Serum leptin concentrations were measured at baseline and analyzed by mean +/- 1S.D. Clinically significantly cognitive decline over 4 years was defined as >= 5-point drop on the Modified Mini Mental State Exam (3MS). Compared to those in the lower leptin groups, elders in the high leptin group had less cognitive decline, 20.5% versus 24.7% (OR=0.79; 95% CI 0.61-1.02, p = 0.07). After adjustment for demographic and clinical variables, including body mass index and total percent body fat, those in the high leptin group had significantly less likelihood of cognitive decline, OR = 0.66 (95% CI 0.48-0.91). We conclude that in elderly individuals, higher serum leptin appears to protect against cognitive decline, independent of comorbidites and body fat. (C) 2007 Elsevier Inc. All rights reserved.

【 授权许可】

Free