No evidence of substantia nigra telomere shortening in Parkinson's disease

NEUROBIOLOGY OF AGING

卷:32

Article

Hudson, Gavin¹  Faini, David¹  Stutt, Andrea²  Eccles, Martin³  Robinson, Louise³  Burn, David J.²  Chinnery, Patrick F.^1,2 

[1] Newcastle Univ, Inst Human Genet, Mitochondrial Res Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

关键词: Parkinson's disease;    Telomere;    Smoking;   

DOI  :  10.1016/j.neurobiolaging.2011.05.022

来源: Elsevier

【 摘 要 】

Telomeres are repetitive tracts of DNA which protect chromosomal integrity. Increased oxidative stress leads to shorter telomeres, which have been associated with several late-onset human diseases. Given independent evidence of oxidative stress and Parkinson's disease (PD), and conflicting reports of the role of telomere length in PD, we measured telomere length in both PD peripheral blood monocytes and in substantia nigra from affected individuals and controls. We confirmed previous findings of a paradoxically longer telomere length in blood from PD patients, but found no difference in telomere length in substantia nigra. Confounding factors provide a likely explanation for the findings in blood, and possibly the reduced frequency of cigarette smoking in PD patients. We conclude that telomere shortening is unlikely to be involved in the pathogenesis of PD. (C) 2011 Elsevier Inc. All rights reserved.

【 授权许可】

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