CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia

NEUROBIOLOGY OF AGING

卷:42

Article

Enache, Daniela^1,2  Solomon, Alina^1,3,4,5  Cavallin, Lena^6,7  Kareholt, Ingemar^4,5,8  Kramberger, Milica Gregoric^1,9  Aarsland, Dag^1,10,11  Kivipelto, Miia^1,3,4,5,10  Eriksdotter, Maria^10,12  Winblad, Bengt^1,10  Jelic, Vesna^10,12 

[1] Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, S-14186 Stockholm, Sweden

[2] Karolinska Univ Hosp, Psychiat Southwest, Huddinge, Sweden

[3] Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

[4] Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, S-14186 Stockholm, Sweden

[5] Stockholm Univ, S-10691 Stockholm, Sweden

[6] Karolinska Inst, Dept Clin Sci Intervent & Technol, S-14186 Stockholm, Sweden

[7] Karolinska Univ Hosp, Dept Radiol, Stockholm, Sweden

[8] Jonkoping Univ, Sch Hlth & Welf, Inst Gerontol, Jonkoping, Sweden

[9] Univ Med Ctr, Dept Neurol, Ljubljana, Slovenia

[10] Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Memory Clin, Stockholm, Sweden

[11] Stavanger Univ Hosp, Ctr Age Related Dis, Psychiat Clin, Stavanger, Norway

[12] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, S-14186 Stockholm, Sweden

关键词: Mild cognitive impairment;    Subjective cognitive impairment;    CAIDE dementia risk score;    Neurodegeneration;    Amyloid beta;    Tau;   

DOI  :  10.1016/j.neurobiolaging.2016.03.007

来源: Elsevier

【 摘 要 】

The aim of this study was to explore cross-sectional associations between Cardiovascular Risk Factors, Aging and Dementia Study (CAIDE) Dementia Risk Score and dementia-related cerebrospinal fluid and neuroimaging biomarkers in 724 patients without dementia from the Memory Clinic at Karolinska University Hospital, Huddinge, Sweden. We additionally evaluated the score's capacity to predict dementia. Two risk score versions were calculated: one including age, gender, obesity, hyperlipidemia, and hypertension; and one additionally including apolipoprotein E (APOE) epsilon 4 carrier status. Cerebrospinal fluid was analyzed for amyloid beta (A beta), total tau, and phosphorylated tau. Visual assessments of medial temporal lobe atrophy (MTA), global cortical atrophy-frontal subscale, and Fazekas scale for white matter changes (WMC) were performed. Higher CAIDE Dementia Risk Score (version without APOE) was significantly associated with higher total tau, more severe MTA, WMC, and global cortical atrophy-frontal subscale. Higher CAIDE Dementia Risk Score (version with APOE) was associated with reduced A beta, more severe MTA, and WMC. CAIDE Dementia Risk Score version with APOE seemed to predict dementia better in this memory clinic population with short follow-up than the version without APOE. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

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