Frontal-subcortical behaviors during Alzheimer's disease in individuals with Down syndrome

NEUROBIOLOGY OF AGING

卷:78

Article

Fonseca, Luciana Mascarenhas^1,2  Mattar, Guilherme Prado¹  Haddad, Glenda Guerra¹  Goncalves, Aline Souza³  Constantino Miguel, Andre de Queiroz⁴  Guilhoto, Laura Maria^5,6  Zaman, Shahid²  Holland, Anthony J.²  de Campos Bottino, Cassio Machado¹  Hoexter, Marcelo Queiroz⁷ 

[1] Univ Sao Paulo, Sch Med, FMUSP, Old Age Res Grp,PROTER,Dept & Inst Psychiat, Sao Paulo, Brazil

[2] Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge, England

[3] Univ Sao Paulo, FMUSP, Sch Med, Lab Neurosci,LIM27 Dept & Inst Psychiat, Sao Paulo, Brazil

[4] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil

[5] Assoc Parents & Friends Individuals Intellectual, Sao Paulo, Brazil

[6] Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil

[7] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat,FMUSP, Obsess Compuls Spectrum Disorders Program,PROTOC, Sao Paulo, Brazil

关键词: Alzheimer's disease;    Down syndrome;    Disinhibition;    Executive dysfunction;    Apathy;    Dementia;   

DOI  :  10.1016/j.neurobiolaging.2019.02.028

来源: Elsevier

【 摘 要 】

There is evidence that frontal-subcortical circuits play an important role in the initial presentation of dementia in Down syndrome (DS), including changes in behavior, a decline in working memory and executive dysfunction. We evaluated 92 individuals with DS (>= 30 years of age), divided into 3 groups by diagnosis-stable cognition, prodromal dementia, and Alzheimer's disease. Each individual was evaluated with an executive protocol developed for people with intellectual disabilities and was rated for behaviors related to frontal lobe dysfunction (disinhibition, executive dysfunction, and apathy) by an informant using the Frontal Systems Behavior Scale. Informant-reported behaviors related to frontal lobe dysfunction were found to correlate negatively with executive function performance. Disinhibition and executive dysfunction were associated with the clinical stage of dementia. The odds of having Alzheimer's disease increased in parallel with increases in the domain and total Frontal Systems Behavior Scale scores (p <= 0.5). Disinhibition, executive dysfunction and apathy should be taken into consideration during the clinical evaluation of adults with DS, and future studies should consider the intersection of neuropathology, brain connectivity, and behavior. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

Free